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Human intraspecific somatic cell hybrids: a genetic and karyotypic analysis of crosses between lymphocytes and D98/AH-2.

Abstract:

A number of human intraspecific hybrids were produced by fusing the 8-azaguanine-resistant cell line D98/AH-2 with PHA-stimulated lymphocytes from a normal human male, followed by selection in HAT medium. The parent cells differed in zymogram patterns for 4 enzyme systems. Hypoxanthine-guanine phophoribosyltransferase was missing in D98/AH-2 and was determined in the hybrids by the normal gene derived from the lymphocyte donor's X chromosome. The HL-A antigens of the lymphocyte donor as well ...

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Publication status:
Published

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Publisher copy:
10.1007/bf01538731

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Publisher:
Kluwer Academic Publishers-Plenum Publishers
Journal:
Somatic cell genetics
Volume:
1
Issue:
1
Pages:
41-64
Publication date:
1975-01-01
DOI:
EISSN:
1572-9931
ISSN:
0098-0366
Source identifiers:
487541

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