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Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension

Abstract:

Bone morphogenetic proteins (BMPs) are secreted ligands of the transforming growth factor-β (TGF-β) family that control embryonic patterning, as well as tissue development and homeostasis. Loss of function mutations in the type II BMP receptor BMPR2 are the leading cause of pulmonary arterial hypertension (PAH), a rare disease of vascular occlusion that leads to high blood pressure in the pulmonary arteries. To understand the structural consequences of these mutations, we determined the cryst...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-019-54830-7

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
ORCID:
0000-0001-6757-0436
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Name:
Wellcome Trust
Grant:
106169/Z/14/Z
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
9
Article number:
18351
Publication date:
2019-12-04
Acceptance date:
2019-11-14
DOI:
EISSN:
2045-2322
Keywords:
Pubs id:
pubs:1072138
UUID:
uuid:f9f06ad1-00e8-48fd-a591-d8221b354345
Local pid:
pubs:1072138
Source identifiers:
1072138
Deposit date:
2019-11-15

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