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The histone demethylase JARID1A is associated with susceptibility to ankylosing spondylitis.

Abstract:

Associations with disease identified by genome-wide association studies (GWAS) must be replicated and refined to validate causative variants. In the Wellcome Trust Case Control Consortium (WTCCC) GWAS using 14 500 non-synonymous single nucleotide polymorphisms (nsSNP), rs11062385 (a nsSNP in JARID1A) showed nominal association with ankylosing spondylitis (AS) (P=0.0006, odds ratio (OR)=1.26, 95% confidence interval (95% CI)=1.1-1.4). To replicate and refine the association of JARID1A, rs11062...

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Publication status:
Published

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Publisher copy:
10.1038/gene.2011.23

Authors


Pointon, JJ More by this author
Karaderi, T More by this author
Appleton, LH More by this author
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Journal:
Genes and immunity
Volume:
12
Issue:
5
Pages:
395-398
Publication date:
2011-07-05
DOI:
EISSN:
1476-5470
ISSN:
1466-4879
URN:
uuid:f9e4a9f3-24f1-451d-8480-547cf3482d74
Source identifiers:
170377
Local pid:
pubs:170377

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