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CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding.

Abstract:

In order to identify potential markers of renal cancer, the plasma membrane protein content of renal cell carcinoma (RCC)-derived cell lines was annotated using a proteomics process. One unusual protein identified at high levels in A498 and 786-O cells was CD70 (TNFSF7), a type II transmembrane receptor normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD70 expression in multiple carcinoma types ...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6603222

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Journal:
British journal of cancer More from this journal
Volume:
95
Issue:
3
Pages:
298-306
Publication date:
2006-08-01
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Language:
English
Keywords:
Pubs id:
pubs:119051
UUID:
uuid:f9d788e4-fc1b-4876-83ae-8a498a4d6704
Local pid:
pubs:119051
Source identifiers:
119051
Deposit date:
2012-12-19

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