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Journal article

Structure of the Helicobacter pylori CagA oncoprotein bound to the human tumor suppressor ASPP2.

Abstract:

The Cytotoxin associated gene A (CagA) protein of Helicobacter pylori is associated with increased virulence and risk of cancer. Recent proteomic studies have demonstrated an association of CagA with the human tumor suppressor Apoptosis-stimulating Protein of p53-2 (ASPP2). We present here a genetic, biochemical, and structural analysis of CagA with ASPP2. Domain delineation of the 120-kDa CagA protein revealed a stable N-terminal subdomain that was used in a yeast two-hybrid screen that iden...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1320631111

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
111
Issue:
4
Pages:
1562-1567
Publication date:
2014-01-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:447805
UUID:
uuid:f9cf0c1b-01a0-4ecc-bdef-761d8d902a1a
Local pid:
pubs:447805
Source identifiers:
447805
Deposit date:
2014-05-09

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