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Directly-observed therapy (DOT) for the radical 14-day primaquine treatment of Plasmodium vivax malaria on the Thai-Myanmar border.

Abstract:

BACKGROUND: Plasmodium vivax has a dormant hepatic stage, called the hypnozoite, which can cause relapse months after the initial attack. For 50 years, primaquine has been used as a hypnozoitocide to radically cure P. vivax infection, but major concerns remain regarding the side-effects of the drug and adherence to the 14-day regimen. This study examined the effectiveness of using the directly-observed therapy (DOT) method for the radical treatment of P. vivax malaria infection, to prevent r...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1475-2875-9-308

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Wellcome Trust More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Malaria Journal Journal website
Volume:
9
Issue:
1
Pages:
Article: 308
Publication date:
2010-01-01
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
URN:
uuid:f9c949c2-593f-4292-8904-64b44a9d515b
Source identifiers:
102692
Local pid:
pubs:102692

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