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Causal associations of adiposity and body fat distribution with coronary heart disease, dtroke dubtypes, and type 2 diabetes mellitus: a Mendelian randomization analysis

Abstract:

The implications of different adiposity measures on cardiovascular disease etiology remain unclear. In this article, we quantify and contrast causal associations of central adiposity (waist-to-hip ratio adjusted for body mass index [WHRadjBMI]) and general adiposity (body mass index [BMI]) with cardiometabolic disease.Ninety-seven independent single-nucleotide polymorphisms for BMI and 49 single-nucleotide polymorphisms for WHRadjBMI were used to conduct Mendelian randomization analyses in 14...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
American Heart Association
Journal:
Circulation More from this journal
Volume:
135
Issue:
24
Pages:
2373-2388
Publication date:
2017-05-12
Acceptance date:
2017-04-03
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Pmid:
28500271
Language:
English
Pubs id:
pubs:695744
UUID:
uuid:f9c5628a-b525-4c6d-836f-9803c55369b9
Local pid:
pubs:695744
Source identifiers:
695744
Deposit date:
2017-11-07

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