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A carbohydrate-antioxidant hybrid polymer reduces oxidative damage in spermatozoa and enhances fertility.

Abstract:

Gamete-gamete interactions are critically modulated by carbohydrate-protein interactions that rely on the carbohydrate-selective recognition of polyvalent carbohydrate structures. A galactose-binding protein has been identified in mammalian spermatozoa that has similarity to the well-characterized hepatic asialoglycoprotein receptor. With the aim of exploiting the ability of this class of proteins to bind and internalize macromolecules displaying galactose, we designed hybrid carbohydrate-ant...

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Publication status:
Published

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Publisher copy:
10.1038/nchembio730

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Journal:
Nature chemical biology More from this journal
Volume:
1
Issue:
5
Pages:
270-274
Publication date:
2005-10-01
DOI:
EISSN:
1552-4469
ISSN:
1552-4450
Language:
English
Keywords:
Pubs id:
pubs:39714
UUID:
uuid:f9c40c08-42b3-4fde-b820-157c0c553c9b
Local pid:
pubs:39714
Source identifiers:
39714
Deposit date:
2012-12-19

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