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Processing of human toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes.

Abstract:

Toll-like receptor 7 (TLR7) triggers antiviral immune responses by recognizing viral single-stranded RNA in endosomes, but the biosynthetic pathway of human TLR7 (hTLR7) remains unclear. Here, we show that hTLR7 is proteolytically processed and that the C-terminal fragment selectively accumulates in endocytic compartments. hTLR7 processing occurred at neutral pH and was dependent on furin-like proprotein convertases (PCs). Furthermore, TLR7 processing was required for its functional response ...

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Publication status:
Published

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Journal:
Immunity More from this journal
Volume:
39
Issue:
4
Pages:
711-721
Publication date:
2013-10-01
DOI:
EISSN:
1097-4180
ISSN:
1074-7613

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