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Prolonged evolution of virus-specific memory T cell immunity post severe avian influenza A (H7N9) virus infection

Abstract:

Since 2013, influenza A/H7N9 has emerged as the commonest avian influenza subtype causing human infection, and is associated with a high fatality risk. However, the characteristics of immune memory in patients who have recovered from H7N9 infection are not well understood. We assembled a cohort of forty-five H7N9 survivors followed for up to 15 months after infection. Humoral and cellular immune responses were analyzed in sequential samples obtained at 1.5-4 months, 6-8 months and 12-15 month...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/jvi.01024-18

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More from this funder
Name:
National Natural Science Foundation of China Innovative Research Group
Funding agency for:
Gao, GF
Grant:
81621091
More from this funder
Name:
National Institute for Health Research
Funding agency for:
Klenerman, P
Grant:
NF-SI-0515-10005
More from this funder
Name:
Wellcome Trust
Funding agency for:
Klenerman, P
Grant:
NF-SI-0515-10005
More from this funder
Name:
National Institutes of Health
Grant:
U19 AI51915
More from this funder
Name:
National Natural Science Foundation of China
Grant:
81373141
Publisher:
American Society of Microbiology
Journal:
Journal of virology More from this journal
Publication date:
2018-06-20
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Pmid:
29925664
Language:
English
Keywords:
Pubs id:
pubs:859025
UUID:
uuid:f9c2b557-b267-4da8-98df-70671ed2aec0
Local pid:
pubs:859025
Source identifiers:
859025
Deposit date:
2018-06-24

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