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Survey of the allelic frequency of a NOS2A promoter microsatellite in human populations: assessment of the NOS2A gene and predisposition to infectious disease.

Abstract:
Allelic frequencies of a (CCTTT)(n) pentanucleotide repeat in the NOS2A promoter region were determined in a total of 1393 unrelated individuals from five specific population groups in four continents: Africa, Europe, Asia, and the Caribbean. There were highly significant differences in allele frequencies between the ethnically diverse populations. The repeat variation may have implications for the selective pressure of malaria or other infectious diseases that may operate at the NOS2 locus.
Publication status:
Published

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Publisher copy:
10.1006/niox.2000.0290

Authors


Humphries, S More by this author
Okuyama, T More by this author
Matsuki, M More by this author
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Journal:
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society
Volume:
4
Issue:
4
Pages:
379-383
Publication date:
2000-08-05
DOI:
EISSN:
1089-8611
ISSN:
1089-8603
URN:
uuid:f9bb3ce1-6dce-4083-bea4-2629f5e48742
Source identifiers:
274386
Local pid:
pubs:274386

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