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Journal article

Tumour-derived laminin α5 (LAMA5) promotes colorectal liver metastasis growth, branching angiogenesis and notch pathway inhibition.

Abstract:

Hepatic metastatic growth is dependent upon stromal factors including the matrisomal proteins that make up the extracellular matrix (ECM). Laminins are ECM glycoproteins with several functions relevant to tumour progression including angiogenesis. We investigated whether metastatic colon cancer cells produce the laminins required for vascular basement membrane assembly as a mechanism for the promotion of angiogenesis and liver metastasis growth. qPCR was performed using human-specific primers...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/cancers11050630

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
ORCID:
0000-0003-2997-4194
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
ORCID:
0000-0001-7454-6653
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
More from this funder
Name:
Cancer Research UK
Grant:
BBRXID
More from this funder
Name:
Academy of Medical Sciences
Publisher:
MDPI
Journal:
Cancers More from this journal
Volume:
11
Issue:
5
Article number:
630
Publication date:
2019-05-06
Acceptance date:
2019-04-30
DOI:
ISSN:
2072-6694
Pmid:
31064120
Language:
English
Keywords:
Pubs id:
pubs:998411
UUID:
uuid:f9b479fd-4533-407e-97e8-44f453fea595
Local pid:
pubs:998411
Source identifiers:
998411
Deposit date:
2019-06-12

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