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Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice.

Abstract:

CD4+ T cells in the mouse can be subdivided into two fractions based on the level of expression of the CD45RB determinant. Previous studies have shown that these subsets are functionally distinct. We have further characterized the properties of these subpopulations in vivo by injecting them into C. B-17 scid mice. The animals restored with the CD45RBhighCD4+ T cell population developed a lethal wasting disease with severe mononuclear cell infiltrates into the colon and elevated levels of IFN-...

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Publication status:
Published

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Publisher copy:
10.1093/intimm/5.11.1461

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
International immunology More from this journal
Volume:
5
Issue:
11
Pages:
1461-1471
Publication date:
1993-11-01
DOI:
EISSN:
1460-2377
ISSN:
0953-8178
Language:
English
Keywords:
Pubs id:
pubs:18580
UUID:
uuid:f9b3968f-2449-4f7b-a06c-bf18a03defd1
Local pid:
pubs:18580
Source identifiers:
18580
Deposit date:
2012-12-19

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