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Journal article

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing.

Abstract:

Cockayne syndrome (CS) is a premature aging disorder characterized by photosensitivity, impaired development and multisystem progressive degeneration, and consists of two strict complementation groups, A and B. Using a yeast two-hybrid approach, we identified the 5'-3' exonuclease SNM1A as one of four strong interacting partners of CSB. This direct interaction was confirmed using purified recombinant proteins-with CSB able to modulate the exonuclease activity of SNM1A on oligonucleotide subst...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gku1279

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
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Journal:
Nucleic acids research
Volume:
43
Issue:
1
Pages:
247-258
Publication date:
2015-01-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:f9ae871b-4b9a-4ff2-85de-9c8095b80a89
Source identifiers:
501562
Local pid:
pubs:501562

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