- Abstract:
-
INTRODUCTION: Expression of the DLL4 (a notch pathway ligand) by tumor-associated endothelium is a postulated marker of vascular maturity and functionality. As vascular functionality is an important parameter defining chemotherapy and oxygen intra-tumoral distribution, we investigated the role of DLL4 expression in tumour vasculature in the efficacy of radio-chemotherapy for HNSCC patients. MATERIALS AND METHODS: Sixty-five biopsy specimens from HNSCC patients with inoperable disease were imm...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s10456-012-9318-5
-
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- Journal:
- Angiogenesis
- Volume:
- 16
- Issue:
- 2
- Pages:
- 343-351
- Publication date:
- 2013-04-05
- DOI:
- EISSN:
-
1573-7209
- ISSN:
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0969-6970
- URN:
-
uuid:f9a4b011-eb61-4474-a1c8-15eff254b60d
- Source identifiers:
-
358352
- Local pid:
- pubs:358352
- Copyright date:
- 2013
Journal article
High DLL4 expression in tumour-associated vessels predicts for favorable radiotherapy outcome in locally advanced squamous cell head-neck cancer (HNSCC).
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