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Journal article

High DLL4 expression in tumour-associated vessels predicts for favorable radiotherapy outcome in locally advanced squamous cell head-neck cancer (HNSCC).

Abstract:

INTRODUCTION: Expression of the DLL4 (a notch pathway ligand) by tumor-associated endothelium is a postulated marker of vascular maturity and functionality. As vascular functionality is an important parameter defining chemotherapy and oxygen intra-tumoral distribution, we investigated the role of DLL4 expression in tumour vasculature in the efficacy of radio-chemotherapy for HNSCC patients. MATERIALS AND METHODS: Sixty-five biopsy specimens from HNSCC patients with inoperable disease were imm...

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Publication status:
Published

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Publisher copy:
10.1007/s10456-012-9318-5

Authors


Journal:
Angiogenesis
Volume:
16
Issue:
2
Pages:
343-351
Publication date:
2013-04-05
DOI:
EISSN:
1573-7209
ISSN:
0969-6970
URN:
uuid:f9a4b011-eb61-4474-a1c8-15eff254b60d
Source identifiers:
358352
Local pid:
pubs:358352

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