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Journal article

Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis.

Abstract:

Hip osteoarthritis (HOA) is one of the most disabling and common joint disorders with a large genetic component that is, however, still ill-defined. To date, genome-wide association studies (GWAS) in osteoarthritis (OA) and specifically in HOA have yielded only few loci, which is partly explained by heterogeneity in the OA definition. Therefore, we here focused on radiographically measured joint-space width (JSW), a proxy for cartilage thickness and an important underlying intermediate trait ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1119899109

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
109
Issue:
21
Pages:
8218-8223
Publication date:
2012-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:f9a0c88b-e12f-4328-912b-fc31a8763557
Source identifiers:
334636
Local pid:
pubs:334636

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