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Failure of intravenous pentagastrin challenge to induce panic-like effects in rhesus monkeys.

Abstract:

We examined the ability of intravenous (i.v.) challenge with pentagastrin to induce behavioural and cardiovascular effects consistent with panic attack in conscious rhesus monkeys. For behavioural evaluation, 4 naive male rhesus monkeys familiar with minimal manual restraint necessary for drug administration received a rapid i.v. bolus of pentagastrin (4, 8 or 16 micrograms/kg) or water on four separate occasions according to a randomised cross-over design. Behaviour was rated by a blind obse...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
Journal:
Neuropeptides More from this journal
Volume:
25
Issue:
2
Pages:
115-119
Publication date:
1993-08-01
DOI:
EISSN:
1532-2785
ISSN:
0143-4179
Language:
English
Keywords:
Pubs id:
pubs:15464
UUID:
uuid:f99e62b6-7fc4-4dd4-add3-11f85e5ba6ba
Local pid:
pubs:15464
Source identifiers:
15464
Deposit date:
2012-12-19

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