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The relationship between blood sample volume and diagnostic sensitivity of blood culture for typhoid and paratyphoid fever: a systematic review and meta-analysis

Abstract:
Background Blood culture is the standard diagnostic method for typhoid and paratyphoid (enteric) fever in surveillance studies and clinical trials, but sensitivity is widely acknowledged to be suboptimal. We conducted a systematic review and meta-analysis to examine sources of heterogeneity across studies and quantified the effect of blood volume. Methods We searched the literature to identify all studies that performed blood culture alongside bone marrow cu... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/infdis/jiy471

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ORCID:
0000-0002-0235-6030
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Paediatrics
Oxford college:
St Cross College
ORCID:
0000-0001-7361-719X
Pitzer, VE More by this author
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of infectious diseases Journal website
Volume:
218
Issue:
S4
Pages:
S255–S267
Publication date:
2018-10-11
Acceptance date:
2018-07-25
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pubs id:
pubs:929692
URN:
uri:f995de3a-3499-4e0d-b975-46c8a64643ba
UUID:
uuid:f995de3a-3499-4e0d-b975-46c8a64643ba
Local pid:
pubs:929692

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