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Risk-directed treatment intensification significantly reduces the risk of relapse among children and adolescents with acute lymphoblastic leukemia and intrachromosomal amplification of chromosome 21: a comparison of the MRC ALL97/99 and UKALL2003 trials.

Abstract:

PURPOSE: To evaluate the effect on outcome of intensifying therapy for patients with acute lymphoblastic leukemia (ALL) and an intrachromosomal amplification of chromosome 21 (iAMP21). PATIENTS AND METHODS: We report two cohorts of patients treated on Medical Research Council ALL97 or United Kingdom (UK) ALL2003. iAMP21 was identified retrospectively in ALL97 and was not used to guide therapy. However, in UKALL2003, iAMP21 was determined prospectively, and patients were allocated to the most ...

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Publication status:
Published

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Publisher copy:
10.1200/jco.2013.48.9377

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Role:
Author
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Journal:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Volume:
31
Issue:
27
Pages:
3389-3396
Publication date:
2013-09-05
DOI:
EISSN:
1527-7755
ISSN:
0732-183X
URN:
uuid:f9935d21-1c49-439b-a296-e9f1d5fc5598
Source identifiers:
418365
Local pid:
pubs:418365

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