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Elevated cortical glutamate in young people at increased familial risk of depression.

Abstract:

Using proton magnetic resonance spectroscopy (MRS), we have demonstrated regional abnormalities in cortical γ-aminobutyric acid (GABA) and glutamate in medication-free recovered depressed patients. It is unclear whether these changes represent an underlying trait vulnerability to depression, or an after-effect of episodes of illness or its treatment. We sought to examine this question by examining a group of high-risk, never-depressed, individuals. We used MRS to measure GABA and glutamate in...

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Publication status:
Published

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Publisher copy:
10.1017/s1461145710001094

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
Journal:
international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) More from this journal
Volume:
14
Issue:
2
Pages:
255-259
Publication date:
2011-03-01
DOI:
EISSN:
1469-5111
ISSN:
1461-1457
Language:
English
Keywords:
Pubs id:
pubs:139504
UUID:
uuid:f987bc14-250f-44bc-9b57-59450a98fc95
Local pid:
pubs:139504
Source identifiers:
139504
Deposit date:
2012-12-19

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