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Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei.

Abstract:

BACKGROUND: Protozoan parasites of the genus Trypanosoma cause disease in a wide range of mammalian hosts. Trypanosoma brucei brucei, transmitted by tsetse fly to cattle, causes a disease (Nagana) of great economic importance in parts of Africa. T. b. brucei also serves as a model for related Trypanosoma species, which cause human sleeping sickness. MATERIALS AND METHODS: Chalcone and acyl hydrazide derivatives are known to retard the growth of Plasmodium falciparum in vitro and inhibit the m...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Flaherty, TM More by this author
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Journal:
Molecular medicine (Cambridge, Mass.)
Volume:
6
Issue:
8
Pages:
660-669
Publication date:
2000-08-05
EISSN:
1528-3658
ISSN:
1076-1551
URN:
uuid:f9830dee-770c-474e-a272-d1931fb35103
Source identifiers:
226501
Local pid:
pubs:226501

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