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Thesis

Role of delta-like 4 in solid tumours and response to radiation therapy

Abstract:

Delta-like ligand 4 (DLL4) is a ligand for the Notch family of receptors. DLL4 is an important regulator of angiogenesis and DLL4 blockade promotes non-productive angiogenesis and delays tumour growth. The aim of this thesis was to investigate the effects of anti-DLL4 therapy in solid tumours in combination with a clinically relevant dose of ionising radiation (5 Gy; IR) and to analyse alterations in the Notch pathway induced by the treatments. Combining both treatments resulted in a great...

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Institution:
University of Oxford
Oxford college:
St Cross College
Department:
Medical Sciences Division - Medical Oncology
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:f977581c-a460-4876-9ce4-dcbe9494aa1e
Local pid:
ora:11452

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