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Conformational and thermodynamic properties of parallel intramolecular triple helices containing a DNA, RNA, or 2 '-OMeDNA third strand

Abstract:

The thermodynamic stability and solution conformational properties of three intramolecular triple helices based on the sequence AGAAGA-x-TCTTCT-x- TCTTCT (x is a non-nucleotide linker) comprising a DNA duplex and DNA, RNA, or 2'-OMeDNA third strands have been compared. The most stable triple helix contains the 2'-OMe third strand, followed by the triplex containing RNA in the third strand. Comparison of the NMR spectroscopic data for the RNA hybrid triplex with those of the all-DNA triplex sh...

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Publication status:
Published

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Publisher copy:
10.1021/ja991949s

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume:
121
Issue:
48
Pages:
11063-11070
Publication date:
1999-12-08
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:f9736d26-ac19-4d90-b5e0-4b867f24521a
Source identifiers:
400251
Local pid:
pubs:400251
Language:
English

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