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Proresolving mediators LXB4 and RvE1 regulate inflammation in stromal cells from patients with shoulder tendon tears

Abstract:

Tendon stromal cells isolated from patients with chronic shoulder rotator-cuff tendon tears show dysregulated resolution responses. Current therapies do not address the biological processes concerned with persistent tendon inflammation, therefore new therapeutic approaches targeting tendon stromal cells are required. We determined if two specialised pro-resolving mediators (SPM) LXB4 and RvE1, modulated the bioactive lipid mediator profiles of IL-1β stimulated tendon cells derived from patien...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
Publisher:
Elsevier
Journal:
American Journal of Pathology More from this journal
Publication date:
2019-08-19
Acceptance date:
2019-07-09
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
Pubs id:
pubs:1030879
UUID:
uuid:f96cc91f-c7bd-403c-b353-875dbb18a650
Local pid:
pubs:1030879
Source identifiers:
1030879
Deposit date:
2019-07-10

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