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A novel technique for detecting antibiotic-resistant typhoid from rapid diagnostic tests.

Abstract:
Fluoroquinolone-resistant typhoid is increasing. An antigen-detecting rapid diagnostic test (RDT) can rapidly diagnose typhoid from blood cultures. A simple, inexpensive molecular technique performed with DNA from positive RDTs accurately identified gyrA mutations consistent with phenotypic susceptibility testing results. Field diagnosis combined with centralized molecular resistance testing could improve typhoid management and surveillance in low-resource settings.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/jcm.00531-15

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Publisher:
American Society of Microbiology
Journal:
Journal of Clinical Microbiology More from this journal
Volume:
53
Issue:
5
Pages:
1758-1760
Publication date:
2015-05-01
DOI:
EISSN:
1098-660X
ISSN:
0095-1137
Language:
English
Pubs id:
pubs:514542
UUID:
uuid:f969376d-5b96-4007-bbf1-7620ac0ef7e6
Local pid:
pubs:514542
Source identifiers:
514542
Deposit date:
2015-12-26

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