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Low-dose irradiation of nontransformed cells stimulates the selective removal of precancerous cells via intercellular induction of apoptosis.

Abstract:

An important stage in tumorigenesis is the ability of a precancerous cell to escape natural anticancer signals imposed on it by neighboring cells and its microenvironment. We have previously characterized a system of intercellular induction of apoptosis whereby nontransformed cells selectively remove transformed cells from coculture via cytokine and reactive oxygen/nitrogen species (ROS/RNS) signaling. We report that irradiation of nontransformed cells with low doses of either high linear ene...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Cancer research More from this journal
Volume:
67
Issue:
3
Pages:
1246-1253
Publication date:
2007-02-01
DOI:
EISSN:
1538-7445
ISSN:
0008-5472

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