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Journal article

Patched 1 expression correlates with biochemical relapse in high-risk prostate cancer patients

Abstract:

There is an unmet clinical need for adequate biomarkers to aid risk stratification and management of prostate cancer (PCa) patients. Even within the high-risk PCa category not all patients will invariably have a poor prognosis, and improved stratification of this heterogeneous group is needed. In this context, components of the hedgehog (Hh) pathway may have promise as biomarkers, as the available evidence suggests increased Hh pathway activity may confer a poorer outcome in advanced and cast...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.ajpath.2017.11.019

Authors


Gonnissen, A More by this author
Isebaert, S More by this author
Perneel, C More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Van Utterbeeck, F More by this author
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Cancer Research UK More from this funder
Academy of Medical Sciences More from this funder
Publisher:
Elsevier Publisher's website
Journal:
American Journal of Pathology Journal website
Volume:
188
Issue:
3
Pages:
795-804
Publication date:
2018-01-12
Acceptance date:
2017-11-20
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
Pubs id:
pubs:821428
URN:
uri:f95d8484-acc5-453d-9a38-6bbb3851fd62
UUID:
uuid:f95d8484-acc5-453d-9a38-6bbb3851fd62
Local pid:
pubs:821428
Language:
English

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