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The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody.

Abstract:

Current vaccine strategies against the asexual blood stage of Plasmodium falciparum are mostly focused on well-studied merozoite antigens that induce immune responses after natural exposure, but have yet to induce robust protection in any clinical trial. Here we compare human-compatible viral-vectored vaccines targeting ten different blood-stage antigens. We show that the full-length P. falciparum reticulocyte-binding protein homologue 5 (PfRH5) is highly susceptible to cross-strain neutraliz...

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Publication status:
Published

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Publisher copy:
10.1038/ncomms1615

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Journal:
Nature communications
Volume:
2
Issue:
1
Pages:
601
Publication date:
2011-01-01
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Source identifiers:
239835

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