- Abstract:
-
Current vaccine strategies against the asexual blood stage of Plasmodium falciparum are mostly focused on well-studied merozoite antigens that induce immune responses after natural exposure, but have yet to induce robust protection in any clinical trial. Here we compare human-compatible viral-vectored vaccines targeting ten different blood-stage antigens. We show that the full-length P. falciparum reticulocyte-binding protein homologue 5 (PfRH5) is highly susceptible to cross-strain neutraliz...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/ncomms1615
-
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- Journal:
- Nature communications
- Volume:
- 2
- Issue:
- 1
- Pages:
- 601
- Publication date:
- 2011
- DOI:
- EISSN:
-
2041-1723
- ISSN:
-
2041-1723
- URN:
-
uuid:f95d7a97-545e-401a-98b0-28689b3f78f6
- Source identifiers:
-
239835
- Local pid:
- pubs:239835
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody.
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