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Ganglion-specific impairment of the norepinephrine transporter in the hypertensive rat

Abstract:

Hypertension is associated with enhanced cardiac sympathetic transmission, although the exact mechanisms underlying this are still unknown. We hypothesized that defective function of the norepinephrine uptake transporter (NET) may contribute to the sympathetic phenotype of the spontaneously hypertensive rat, and that this may occur before the development of hypertension itself. The dynamic kinetics of NET were monitored temporally using a novel fluorescent assay of the transporter in cultured...

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Journal:
Hypertension More from this journal
Volume:
61
Issue:
1
Pages:
187-193
Publication date:
2013-01-01
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Language:
English
Keywords:
Pubs id:
pubs:371471
UUID:
uuid:f95cec4f-edd0-4738-a119-553c082d04d1
Local pid:
pubs:371471
Source identifiers:
371471
Deposit date:
2013-11-17

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