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Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity.

Abstract:

Vaccination of mice with a peptide corresponding to the extracellular part of M2 protein coupled to the immunodominant domain of hepatitis B core can protect mice from a lethal challenge with influenza A virus. As the extracellular part of M2 protein is highly conserved in all known human influenza A strains, such a vaccine may protect against all human influenza A strains, which would represent a major advantage over current vaccine strategies. The present study demonstrates that protection ...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.172.9.5598

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Journal:
Journal of Immunology More from this journal
Volume:
172
Issue:
9
Pages:
5598-5605
Publication date:
2004-05-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767

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