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Pharmacokinetic and pharmacodynamic considerations in antimalarial dose optimization.

Abstract:

Antimalarial drugs have usually been first deployed in areas of malaria endemicity at doses which were too low, particularly for high-risk groups such as young children and pregnant women. This may accelerate the emergence and spread of resistance, thereby shortening the useful life of the drug, but it is an inevitable consequence of the current imprecise method of dose finding. An alternative approach to dose finding is suggested in which phase 2 studies concentrate initially on pharmacokine...

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Publication status:
Published

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Publisher copy:
10.1128/aac.00287-13

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
Journal:
Antimicrobial agents and chemotherapy
Volume:
57
Issue:
12
Pages:
5792-5807
Publication date:
2013-12-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:f953a4f9-ffe7-4e48-9b2d-235ebbcdd7ab
Source identifiers:
421073
Local pid:
pubs:421073

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