- Abstract:
-
Antimalarial drugs have usually been first deployed in areas of malaria endemicity at doses which were too low, particularly for high-risk groups such as young children and pregnant women. This may accelerate the emergence and spread of resistance, thereby shortening the useful life of the drug, but it is an inevitable consequence of the current imprecise method of dose finding. An alternative approach to dose finding is suggested in which phase 2 studies concentrate initially on pharmacokine...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/aac.00287-13
-
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- Journal:
- Antimicrobial agents and chemotherapy
- Volume:
- 57
- Issue:
- 12
- Pages:
- 5792-5807
- Publication date:
- 2013-12-05
- DOI:
- EISSN:
-
1098-6596
- ISSN:
-
0066-4804
- URN:
-
uuid:f953a4f9-ffe7-4e48-9b2d-235ebbcdd7ab
- Source identifiers:
-
421073
- Local pid:
- pubs:421073
- Copyright date:
- 2013
Journal article
Pharmacokinetic and pharmacodynamic considerations in antimalarial dose optimization.
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