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A role beyond learning for NMDA receptors in reward-based decision-making-a pharmacological study using d-cycloserine.

Abstract:

N-methyl-D-aspartate (NMDA) receptors are known to fulfill crucial functions in many forms of learning and plasticity. More recently, biophysical models, however, have suggested an additional role of NMDA receptors in evidence integration for decision-making, going beyond their role in learning. We designed a task to study the role of NMDA receptors in human reward-guided learning and decision-making. Human participants were assigned to receive either 250 mg of the partial NMDA agonist d-cycl...

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Publication status:
Published

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Publisher copy:
10.1038/npp.2014.144

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Günthner, J More by this author
Kolling, N More by this author
Favaron, E More by this author
Rushworth, MF More by this author
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Journal:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volume:
39
Issue:
12
Pages:
2900-2909
Publication date:
2014-11-05
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
URN:
uuid:f9528a8e-2c6d-4474-af8f-2a80b0449c3c
Source identifiers:
469575
Local pid:
pubs:469575
Language:
English

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