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Biochemical analysis of the Plasmodium falciparum erythrocyte-binding antigen-175 (EBA175)-glycophorin-A interaction: implications for vaccine design.

Abstract:

PfEBA175 has an important role in the invasion of human erythrocytes by Plasmodium falciparum and is therefore considered a high priority blood-stage malaria vaccine candidate. PfEBA175 mediates adhesion to erythrocytes through binding of the Duffy-binding-like (DBL) domains in its extracellular domain to Neu5Acα2-3Gal displayed on the O-linked glycans of glycophorin-A (GYPA). Because of the difficulties in expressing active full-length (FL) P. falciparum proteins in a recombinant form, previ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m113.484840
Journal:
Journal of biological chemistry More from this journal
Volume:
288
Issue:
45
Pages:
32106-32117
Publication date:
2013-11-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Language:
English
Keywords:
Pubs id:
pubs:440440
UUID:
uuid:f94fcb10-8811-4680-816e-bbd5120ca44f
Local pid:
pubs:440440
Source identifiers:
440440
Deposit date:
2014-02-08

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