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Journal article

Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration

Abstract:

Runx1 is a transcription factor that plays a key role in determining the proliferative and differential state of multiple cell types, during both development and adulthood. Here, we report how Runx1 is specifically upregulated at the injury site during zebrafish heart regeneration, and that absence of runx1 results in increased myocardial survival and proliferation, and overall heart regeneration, accompanied by decreased fibrosis. Using single cell sequencing, we found that the wild-type inj...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/dev.186569

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More from this funder
Name:
European Commission
Grant:
715895
More from this funder
Name:
British Heart Foundation
Grant:
PG/15/111/31939
Publisher:
Company of Biologists
Journal:
Development More from this journal
Volume:
147
Issue:
8
Pages:
dev186569
Publication date:
2020-04-27
Acceptance date:
2020-03-04
DOI:
EISSN:
1477-9129
ISSN:
0951-1991
Language:
English
Keywords:
Pubs id:
1102213
Local pid:
pubs:1102213
Deposit date:
2020-04-28

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