Journal article icon

Journal article

Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis

Abstract:

With the functional demonstration of a role in erythrocyte invasion by Plasmodium falciparum parasites, implications in the aetiology of common conditions that prevail in individuals of African origin, and a wealth of pharmacological knowledge, the stimulatory G protein (Gs) signal transduction pathway presents an exciting target for anti-malarial drug intervention. Having previously demonstrated a role for the G-alpha-s gene, GNAS, in severe malaria disease, we sought to identify other impor...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0010017

Authors


More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Fry, AE
More from this funder
Funding agency for:
Kwiatkowski, DP
Medical Research Council More from this funder
Expand funders...
Journal:
PLoS One Journal website
Volume:
5
Issue:
4
Pages:
e10017-e10017
Publication date:
2010-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:f941bbf6-44d3-4749-9863-3c3f8102c337
Source identifiers:
53295
Local pid:
pubs:53295

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP