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Thesis

Genome-wide analyses reveal new insights into MLL fusion protein recruitment mechanisms

Abstract:

Leukaemias arising from rearrangements of the MLL1 gene are responsible for the majority of infant leukaemias as well as a proportion of childhood and adult leukaemias. The aggressive nature and resistance to therapy of these leukaemias has made them the focus of many therapeutic studies. Targeted therapies for MLL-rearranged (MLL-r) leukaemias are starting to enter clinical trials in an attempt to improve on outcomes from more standard treatments such as chemotherapy.

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Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Department:
University of Oxford
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
More from this funder
Name:
Medical Research Council
Funding agency for:
Milne, T
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Subjects:
UUID:
uuid:f940e8b9-ef9a-45f7-be0b-323f6f32481b
Deposit date:
2016-08-08

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