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Thesis

Genome-wide analyses reveal new insights into MLL fusion protein recruitment mechanisms

Abstract:

Leukaemias arising from rearrangements of the MLL1 gene are responsible for the majority of infant leukaemias as well as a proportion of childhood and adult leukaemias. The aggressive nature and resistance to therapy of these leukaemias has made them the focus of many therapeutic studies. Targeted therapies for MLL-rearranged (MLL-r) leukaemias are starting to enter clinical trials in an attempt to improve on outcomes from more standard treatments such as chemotherapy.

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Department:
University of Oxford
Role:
Copyright Holder, Author

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Department:
molmed
Role:
Supervisor
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Funding agency for:
Thomas Milne
Type of award:
DPhil
Awarding institution:
University of Oxford
Language:
English
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