Journal article icon

Journal article

Tissue-specific regulation of microvascular diameter: opposite functional roles of neuronal and smooth muscle located vanilloid receptor-1.

Abstract:

The transient receptor potential type V1 channel (vanilloid receptor 1, TRPV1) is a Ca(2+)-permeable nonspecific cation channel activated by various painful stimuli including ischemia. We hypothesized that TRPV1 is expressed in the arterioles and is involved in the regulation of microvascular tone. We found that TRPV1 stimulation by capsaicin (intra-arterial administration) of the isolated, perfused right hind limb of the rat increased vascular resistance (by 98 +/- 21 mm Hg at 10 mug) in ass...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1124/mol.107.043323

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Molecular pharmacology More from this journal
Volume:
73
Issue:
5
Pages:
1405-1412
Publication date:
2008-05-01
DOI:
EISSN:
1521-0111
ISSN:
0026-895X
Language:
English
Keywords:
Pubs id:
pubs:164585
UUID:
uuid:f9334875-50dd-4df3-9bf5-30923934fb14
Local pid:
pubs:164585
Source identifiers:
164585
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP