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MicroRNA-148b targets the TGF-β pathway to regulate angiogenesis and endothelial-to-mesenchymal transition during skin wound healing

Abstract:

Transforming growth factor beta (TGF-β) is crucial for regulation of the endothelial cell (EC) homeostasis. Perturbation of TGF-β signaling leads to pathological conditions in the vasculature, causing cardiovascular disease and fibrotic disorders. The TGF-β pathway is critical in endothelial-to-mesenchymal transition (EndMT), but a gap remains in our understanding of the regulation of TGF-β and related signaling in the endothelium. This study applied a gain- and loss-of function approach and ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.ymthe.2018.05.002

Authors


Miscianinov, V More by this author
Martello, A More by this author
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ORCID:
0000-0003-1651-8253
Cathcart, B More by this author
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Funding agency for:
Al Haj Zen, A
Publisher:
Elsevier Publisher's website
Journal:
Molecular Therapy Journal website
Volume:
26
Issue:
8
Pages:
1996-2007
Publication date:
2018-05-08
Acceptance date:
2018-05-04
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
Pubs id:
pubs:854516
URN:
uri:f930875c-a80b-422a-9d83-6deb15c4b33d
UUID:
uuid:f930875c-a80b-422a-9d83-6deb15c4b33d
Local pid:
pubs:854516

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