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Abrogation of E-cadherin-mediated cell-cell contact in mouse embryonic stem cells results in reversible LIF-independent self-renewal.

Abstract:

We have previously demonstrated that differentiation of embryonic stem (ES) cells is associated with downregulation of cell surface E-cadherin. In this study, we assessed the function of E-cadherin in mouse ES cell pluripotency and differentiation. We show that inhibition of E-cadherin-mediated cell-cell contact in ES cells using gene knockout (Ecad(-/-)), RNA interference (EcadRNAi), or a transhomodimerization-inhibiting peptide (CHAVC) results in cellular proliferation and maintenance of an...

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Publication status:
Published

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Publisher copy:
10.1002/stem.134

Authors


Mohamet, L More by this author
Eckardt, D More by this author
Eastham, AM More by this author
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Journal:
Stem cells (Dayton, Ohio)
Volume:
27
Issue:
9
Pages:
2069-2080
Publication date:
2009-09-05
DOI:
EISSN:
1549-4918
ISSN:
1066-5099
URN:
uuid:f92ec608-c36d-49f8-8fdd-2f3269aaddb2
Source identifiers:
58758
Local pid:
pubs:58758

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