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Predicting inter-species cross-talk in two-component signalling systems.

Abstract:

Phosphosignalling pathways are an attractive option for the synthetic biologist looking for a wide repertoire of modular components from which to build. We demonstrate that two-component systems can be used in synthetic biology. However, their potential is limited by the fact that host cells contain many of their own phosphosignalling pathways and these may interact with, and cross-talk to, the introduced synthetic components. In this paper we also demonstrate a simple bioinformatic tool that...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0037737

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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
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Author
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Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
7
Issue:
5
Pages:
e37737
Publication date:
2012-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:f92ccda6-7cfb-4a37-bd3b-3925d74e4c0b
Source identifiers:
332915
Local pid:
pubs:332915

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