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Single molecules can operate as primitive biological sensors, switches and oscillators

Abstract:
Background Switch-like and oscillatory dynamical systems are widely observed in biology. We investigate the simplest biological switch that is composed of a single molecule that can be autocatalytically converted between two opposing activity forms. We test how this simple network can keep its switching behaviour under perturbations in the system. Results We show that this molecule can work as a robust bistable system, even for alterations in the reactions t... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12918-018-0596-4

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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Oxford college:
St Anne's College
Role:
Author
ORCID:
0000-0002-8705-8488
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Name:
Royal Society
Grant:
RP120138
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Name:
European Social Fund
Grant:
EFOP-3.6.2–16–2017-00013
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Name:
Microsoft Research
Grant:
PhD Scholarship Programme
Publisher:
BioMed Central
Journal:
BMC Systems Biology More from this journal
Volume:
12
Article number:
70
Publication date:
2018-06-18
Acceptance date:
2018-06-04
DOI:
ISSN:
1752-0509
Keywords:
Pubs id:
pubs:854815
UUID:
uuid:f92b7cfe-0678-4105-b1b4-cc0bafcdce7f
Local pid:
pubs:854815
Source identifiers:
854815
Deposit date:
2018-06-04

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