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AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis.

Abstract:

Oxidative stress is a principal cause of DNA damage, and mechanisms to repair this damage are among the most highly conserved of biological processes. Oxidative stress is also used by phagocytes to attack bacterial pathogens in defence of the host. We have identified and characterised two apurinic/apyrimidinic (AP) endonuclease paralogues in the human pathogen Neisseria meningitidis. The presence of multiple versions of DNA repair enzymes in a single organism is usually thought to reflect red...

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Publication status:
Published

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Publisher copy:
10.1038/sj.emboj.7601593

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
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Journal:
The EMBO journal
Volume:
26
Issue:
5
Pages:
1363-1372
Publication date:
2007-03-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:f92ac0f0-d64c-4948-a906-1994c90bb395
Source identifiers:
72856
Local pid:
pubs:72856

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