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Factors affecting template switch recombination associated with restarted DNA replication

Abstract:

Homologous recombination helps ensure the timely completion of genome duplication by restarting collapsed replication forks. However, this beneficial function is not without risk as replication restarted by homologous recombination is prone to template switching (TS) that can generate deleterious genome rearrangements associated with diseases such as cancer. Previously we established an assay for studying TS in Schizosaccharomyces pombe (Nguyen et al., 2015). Here, we show that TS is detected...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.41697

Authors


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Role:
Author
ORCID:
0000-0002-4467-4934
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Weatherall Institute of Molecular Medicine
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0003-0951-3374
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Name:
Medical Research Council
Grant:
MR/P028292/1
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Name:
Wellcome Trust
Grant:
090767/Z/09/Z
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Name:
Biotechnology & Biological Sciences Research Council
Grant:
BB/P019706/1
Publisher:
eLife Sciences Publications
Journal:
eLife More from this journal
Volume:
8
Pages:
e41697
Publication date:
2019-01-22
Acceptance date:
2019-01-21
DOI:
EISSN:
2050-084X
Language:
English
Pubs id:
pubs:965581
UUID:
uuid:f9297f83-f826-4229-b2be-65ccb66abb48
Local pid:
pubs:965581
Source identifiers:
965581
Deposit date:
2019-01-22

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