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Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.

Abstract:

OBJECTIVE: Common variation in the FTO gene is associated with BMI and type 2 diabetes. Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides. We aimed to test whether FTO genotype is associated with variation in these metabolic traits. RESEARCH DESIGN AND METHODS: We tested the association between FTO genotype and 10 metabolic traits using data from 17,037 white European individuals. We compared the observed effect of FTO genotype on eac...

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Publication status:
Published

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Publisher copy:
10.2337/db07-1466

Authors


Freathy, RM More by this author
Timpson, NJ More by this author
Lawlor, DA More by this author
Ben-Shlomo, Y More by this author
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Journal:
Diabetes
Volume:
57
Issue:
5
Pages:
1419-1426
Publication date:
2008-05-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:f9281176-63d1-4907-9d26-9e529ef2395e
Source identifiers:
11396
Local pid:
pubs:11396

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