Journal article
Happy mapping: linkage mapping using a physical analogue of meiosis.
- Abstract:
-
We have devised a simple method for ordering markers on a chromosome and determining the distances between them. It uses haploid equivalents of DNA and the polymerase chain reaction, hence 'happy mapping'. Our approach is analogous to classical linkage mapping; we replace its two essential elements, chromosome breakage and segregation, by in vitro analogues. DNA from any source is broken randomly by gamma-irradiation or shearing. Markers are then segregated by diluting the resulting fragments...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/nar/21.1.13
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Authors
Bibliographic Details
- Journal:
- Nucleic acids research
- Volume:
- 21
- Issue:
- 1
- Pages:
- 13-20
- Publication date:
- 1993-01-01
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
- Source identifiers:
-
28757
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:28757
- UUID:
-
uuid:f925d0d7-e4fa-4683-90ee-2fb7b37cda61
- Local pid:
- pubs:28757
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1993
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