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A whole genome association study of neuroticism using DNA pooling.

Abstract:

We describe a multistage approach to identify single nucleotide polymorphisms (SNPs) associated with neuroticism, a personality trait that shares genetic determinants with major depression and anxiety disorders. Whole genome association with 452 574 SNPs was performed on DNA pools from approximately 2000 individuals selected on extremes of neuroticism scores from a cohort of 88 142 people from southwest England. The most significant SNPs were then genotyped on independent samples to replicate...

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Publication status:
Published

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Publisher copy:
10.1038/sj.mp.4002048

Authors


Shifman, S More by this author
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Journal:
Molecular psychiatry
Volume:
13
Issue:
3
Pages:
302-312
Publication date:
2008-03-05
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
URN:
uuid:f924b9f9-d73f-4eed-b782-d5e82587d674
Source identifiers:
33931
Local pid:
pubs:33931

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