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Journal article

Fluorescently labeled risedronate and related analogues: "magic linker" synthesis.

Abstract:
We report synthesis of the first fluorescently labeled conjugates of risedronate (1), using an epoxide linker strategy enabling conjugation of 1 via its pyridyl nitrogen with the label (carboxyfluorescein). Unlike prior approaches to create fluorescent bisphosphonate probes, the new linking chemistry did not abolish the ability to inhibit protein prenylation in vitro, while significantly retaining hydroxyapatite affinity. The utility of a fluorescent 1 conjugate in visualizing osteoclast resorption in vitro was demonstrated.
Publication status:
Published

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Publisher copy:
10.1021/bc800369c

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Journal:
Bioconjugate chemistry More from this journal
Volume:
19
Issue:
12
Pages:
2308-2310
Publication date:
2008-12-01
DOI:
EISSN:
1520-4812
ISSN:
1043-1802
Language:
English
Keywords:
Pubs id:
pubs:109233
UUID:
uuid:f90fff1a-61dc-4d1b-93d9-0e65664c4494
Local pid:
pubs:109233
Source identifiers:
109233
Deposit date:
2013-11-16

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