Journal article icon

Journal article

Reductive site-selective atypical C,Z-type/N2-C2 cleavage allows C-terminal protein amidation

Abstract:

Biomolecule environments can enhance chemistries with the potential to mediate and modulate self-modification (e.g., self-cleavage). While these enhanced modes are found in certain biomolecules (e.g., RNA ribozymes), it is more rare in proteins. Targeted proteolytic cleavage is vital to physiology, biotechnology, and even emerging therapy. Yet, purely chemically induced methods for the site-selective cleavage of proteins remain scarce. Here, as a proof of principle, we designed and tested a s...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1126/sciadv.abl8675

Authors


More by this author
Role:
Author
ORCID:
0000-0003-2951-1368
More by this author
Role:
Author
ORCID:
0000-0001-8960-553X
More by this author
Role:
Author
ORCID:
0000-0001-7760-4329
More by this author
Role:
Author
ORCID:
0000-0002-6628-1912
More by this author
Role:
Author
ORCID:
0000-0002-1840-5706
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/P026311/1
Publisher:
American Association for the Advancement of Science
Journal:
Science Advances More from this journal
Volume:
8
Issue:
14
Article number:
eabl8675
Place of publication:
United States
Publication date:
2022-04-08
Acceptance date:
2022-02-17
DOI:
EISSN:
2375-2548
ISSN:
2375-2548
Pmid:
35394836
Language:
English
Keywords:
Pubs id:
1250253
Local pid:
pubs:1250253
Deposit date:
2022-11-07

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP