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Polydisperse chaperone proteins and the mechanisms by which they inhibit aggregation

Abstract:

The small heat-shock proteins (sHSPs) are ATP-independent molecular chaperones, found in all kingdoms of life. In humans their malfunction is associated with neurodegenerative disease, cataracts, myopathies and cancer. Their molecular mechanism is contentious as sHSPs are challenging experimental targets: they typically exist as large, polydisperse and exchanging oligomers. This heterogeneity is com- pounded by that of aggregating substrates.

Here I investigate the structure, dynami...

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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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