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A drosophila genetic model of nephrolithiasis: transcriptional changes in response to diet induced stone formation

Abstract:

Urolithiasis is a significant healthcare issue but the pathophysiology of stone disease remains poorly understood. Drosophila Malpighian tubules were known to share similar physiological function to human renal tubules. We have used Drosophila as a genetic model to study the transcriptional response to stone formation secondary to dietary manipulation.Wild-type male flies were raised on standard medium supplemented with lithogenic agents: control, sodium oxalate (NaOx) and ethylene glycol (EG...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Publisher:
BioMed Central
Journal:
BMC Urology More from this journal
Volume:
17
Issue:
1
Pages:
Articlce: 109
Publication date:
2017-11-28
Acceptance date:
2017-10-30
DOI:
EISSN:
1471-2490
ISSN:
1471-2490
Pmid:
29183349
Language:
English
Keywords:
Pubs id:
pubs:810042
UUID:
uuid:f8ffd79c-9b40-4593-a150-4aad747d8ea7
Local pid:
pubs:810042
Source identifiers:
810042
Deposit date:
2019-06-29

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